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  • The U.S. Food and Drug Administration has approved the usage of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in grown-ups with a body mass index (BMI) in excess of 27, provided that they also experience weight-related health problems such as Tupe2 diabestes, high cholesterol and/or hypertension (high blood pressure).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder in addition to being an aid to stopping smoking treatment.’Obesity continues to be a major public health concern,’ said Jean-Marc Guettier, M.D., director from the Division of Metabolism and Endocrinology Products in FDA’s Center for Drug Evaluation and Research. ‘When used as directed in combination with a healthy lifestyle that features a reduced-calorie exercise and dieting, Contrave provides another treatment selection for chronic weight loss for people who are obese or are overweight and possess at least one weight-related health condition.’The drug’s effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that contained a reduced- calorie diet and regular exercise. Results from a clinical study that enrolled patients without diabetes demonstrated that patients had an average weight loss of four.1% instead of participants who have been given placebos) after a 12- month period, while a separate study involving patients with diabetes had an average weight loss of 2% over treatment with placebo at one full year.

    Using two separate drugs to lose weight naturally can be very effective there are combinations before the FDA now awaiting approval. When dealing with fat loss and the individuals who go through it you should err on the side of caution and let the FDA do its job and demand some investigation be done so the public understands the side effects and dangers of the medications before we take them. Keep in mind that drug companies come in business to make money and that they would say anything to keep people on their own medications.

    Researchers found that participants investing in this drug to get a year, lost excess weight within 4 weeks and have kept the weight off through the 56 weeks in the study. Contrave is a combination from the drugs naltrexone and bupropion, which generally seems to reflect a brand new trend of weight-loss drugs which are made up of multiple active ingredient, which can make them more effective and safer.

    Combo-pilling will be the newest fad or even better the newest in the future under scrutiny and therefore it is just more publicly known in recent months, comb-pilling for losing weight has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular will be the fact that at the time of right now there aren’t long term prescription weight loss supplements that have been authorized by the FDA aside from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be licensed by the FDA.

    Seizures are a side effect with Contrave and mustn’t be taken in people with seizure disorders. The drug also can raise blood pressure levels and pulse rate, and must not be used in those with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug.

    The FDA also warned that Contrave can raise blood pressure and heartrate and must stop used in patients with uncontrolled high blood pressure, along with by you aren’t heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients having a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients towards the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stopping smoking.

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