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Evidence is increasing that every addiction without exception is related to problems with the brain’s reward center, specially the mesolimbic system. This section of the problem regulates reward responses in acquiring food and sex, along with nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both once they malfunction and when they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates “the level of dopamine released in in reply to a stimulus”(Bostwick & Bucci, 2008).
Using two separate drugs to shed weight can be very effective you can find combinations as you’re watching FDA now awaiting approval. When dealing with weight loss and the people who go through it you should err along the side of caution and allow the FDA do its job and demand some investigation be done in order that the public is aware of the side effects and dangers of the medications before we bring them. Keep in mind that drug companies will be in business to generate income and that they would say everything to keep people on their medications.
Researchers found that participants taking this drug to get a year, lost excess weight within four weeks and have kept the body weight off through the 56 weeks in the study. Contrave is a combination with the drugs naltrexone and bupropion, which generally seems to reflect a brand new trend of weight-loss drugs which are made up of several active ingredient, which might make them more potent and safer.
Combo-pilling may be the newest fad or also the newest in the future under scrutiny and therefore it is just more publicly known in recent months, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills has become popular will be the fact that by right now there aren’t any long term prescription diet pills that have been approved by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be authorized by the FDA.
Seizures can be a side effect with Contrave and must not be taken in people who have seizure disorders. The drug could also raise blood pressure level and pulse rate, and really should not be used in individuals with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug.
The FDA also warned that Contrave can raise blood pressure and heart rate and must stop used in patients with uncontrolled high blood pressure, in addition to by you are not heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients which has a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes having a boxed warning to alert health care professionals and patients on the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking.
Most of the combinations that are used to enhance weight loss involve an amphetamine with an antidepressant. Phentermine and Prozac are a popular combination which have been around for some time, and although it has been around my own mail to truly combine the 2 and try to get FDA approval to showcase it as a weight reduction pill. Right there should raise some warning flag if the greedy pharmaceutical companies should not be involved in combining medications and selling them something should be wrong while using combination. In fairness there exists one fat loss combination pill that is certainly in front of the FDA now Contrave?which couples naltrexone, accustomed to treat alcohol and substance abuse, with all the antidepressant bupropion (Wellbutrin, Zyban) it has been given the go ahead to move forward by an FDA advisory committee, but by yet hasn’t been approved.