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  • The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment selection for chronic weight-loss in addition to a reduced-calorie diet and exercising.

    Using two separate drugs to shed pounds can be very effective you’ll find combinations while watching FDA now awaiting approval. When dealing with weight loss and the people that go through it one should err to the side of caution and allow FDA do its job and demand some study be done so the public is aware of the side effects and dangers of the medications before we take them. Keep in mind that drug companies will be in business to generate income and that they would say everything to keep people on his or her medications.

    Researchers found that participants using this drug for a year, dropped a few pounds within four weeks and have kept the weight off throughout the 56 weeks with the study. Contrave is often a combination in the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs which are made up of several active ingredient, which might make them far better and safer.

    Combo-pilling could be the newest fad or also the newest into the future under scrutiny and for that reason it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is now popular could be the fact that since right now there aren’t long term prescription weightloss pills that have been approved by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be licensed by the FDA.

    Seizures are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug could also raise blood pressure levels and pulse rate, and really should not be used in people who have a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug.

    The FDA also warned that Contrave can raise blood pressure levels and heart rate and must stop used in patients with uncontrolled high blood pressure level, along with by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting the mind) disease. Patients which has a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes having a boxed warning to alert medical researchers and patients towards the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking.

    Approving a drug with this particular many potentially lethal negative effects is inconsistent with the mission statement from the FDA. The power in the drug manufacturing lobby is blatantly evident inside the approval of numerous drugs requiring ‘post-marketing’ studies which are clearly significant to overall drug safety inside US.